hrp0097p1-40 | Diabetes and Insulin | ESPE2023

Neopterin and tryptophan pathways in children with type 1 diabetes: isoxanthopteridine as a marker of endothelial dysfunction

Evliyaoğlu Olcay , Özer Yavuz , Kıykım Ertuğrul , Serif Cansever Mehmet , Turan Hande , Bayramoglu Elvan , Ceyhun Emre , İşat Esra , Zübarioğlu Tanyel , Cigdem Aktuglu Zeybek Ayse

Introduct&idot;on: Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by damage to β cells in the pancreas. Neopterins and indolamine 2,3-dioxygenase (IDO) activity, which is shown by the ratio of kynurenine to tryptophan, can be used as an indicator in the regulation of cellular immunity. Oxidative stress produced by xanthine oxidoreductase has been shown to be associated with vascular endothelial dysfunction. It uses the conversion of p...